Evidence-Based

The Science Behind Neural Recovery

Explore the groundbreaking research that powers our neurorehabilitation platform, from Hebbian plasticity to closed-loop brain-computer interfaces.

Neuroscience

Core Principles

01 — Hebbian Learning

Neurons That Fire Together, Wire Together

Donald Hebb's principle forms the foundation of neural plasticity. When neurons are activated simultaneously, synaptic connections strengthen through Long-Term Potentiation (LTP). Our 500ms predictive window ensures brain intent forms before movement, maximizing this effect.

Hebb, D.O. (1949). The Organization of Behavior. Wiley.

Click neurons to see Hebbian strengthening

Move mouse over the hand to activate mirror neurons

02 — Mirror Neurons

See It, Feel It, Recover It

Discovered by Rizzolatti's team, mirror neurons fire both during action execution AND observation. Virtual limbs performing perfect movements create consistent success feedback, activating the motor cortex and promoting neural reorganization even in severely affected limbs.

Rizzolatti, G. et al. (1996). Cognitive Brain Research.

03 — Melodic Intonation

Music as Neural Medicine

Rhythmic musical elements engage the right hemisphere to bypass damaged language areas. The predictable temporal structure of music provides scaffolding for motor planning, while rhythm entrainment synchronizes neural oscillations across brain regions.

Schlaug G et al. (2010). Music Perception.

Click nodes to jump the signal

04 — Closed-Loop BCI

Intent → Action → Feedback

Traditional rehabilitation is open-loop. Our closed-loop system creates continuous feedback: EEG detects motor intent → game responds with visual/auditory action → patient perceives success → neural pathway strengthens. This real-time contingency maximizes neuroplastic change.

Daly, J.J. & Wolpaw, J.R. (2008). Lancet Neurology.

Hardware

Multi-Modal Sensing

Emotiv EEG

14-channel wireless EEG headset capturing focus, relaxation, and motor imagery signals. Real-time brainwave analysis via Cortex API enables precise detection of motor intent before physical movement occurs.

Apple Watch

High-precision accelerometer and gyroscope data at 100Hz for movement tracking. 500ms haptic priming delivers rhythm cues before expected movements, preparing the motor system for action.

Computer Vision

MediaPipe hand tracking provides 21 3D landmarks per hand at 30fps using just a standard webcam. Deep learning models enable precise finger movement detection for fine motor rehabilitation exercises.

Key References

Hebbian Learning

Hebb, D.O. (1949). The Organization of Behavior. Wiley.

Mirror Neurons

Rizzolatti, G. et al. (1996). Cognitive Brain Research, 3(2).

BCI Rehabilitation

Daly, J.J. & Wolpaw, J.R. (2008). Lancet Neurology, 7(11).

Mirror Therapy

Ramachandran, V.S. (2009). Brain, 132(7).